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Yposkesi selected by Orchard Therapeutics to produce lentiviral vectors for gene therapies in clinical trials

Yposkesi has been selected by Orchard Therapeutics to produce lentiviral gene therapy vectors for clinical trials

London (United Kingdom) and Corbeil-Essonnes (France), December 18 th 2017 – Orchard Therapeutics (“Orchard”), a clinical-stage biotechnology company dedicated to transforming the lives of patients with rare disorders through innovative gene therapies, announces today a manufacturing agreement with Yposkesi, a leading manufacturing organization for gene and cell therapy products created by AFM-Téléthon and the SPI fund managed by Bpifrance.

Yposkesi provides its expertise and production capacity to Orchard Therapeutics’ projects. As part of this partnership, Yposkesi will produce lentiviral vector batches to meet Orchard’s needs for clinical trialsin primary immune deficiencies including X-linked chronic granulomatous (X-CGD) disease.

Mark Rothera, Chief Executive Officer of Orchard Therapeutics comments: “We are excited to work with Yposkesi, an industrial leader in the manufacturing of advanced therapy products. This partnership will help to accelerate the development of Orchard’s transformative gene therapy medicines in some severe hereditary diseases. Yposkesi and Orchard are working to reach a common goal to improve the length and quality of patients’ lives.”.

“We are proud to count Orchard Therapeutics among Yposkesi’s customers, and to contribute to innovative therapies development for pathologies for which a therapeutic solution does not exist yet. This agreement is a further proof of Yposkesi’s expertise in gene therapy drug production and demonstrates how actors of tomorrow’s treatment trust in us”, added Alain Lamproye, CEO of Yposkesi.


About Orchard Therapeutics

Orchard Therapeutics is a privately-held clinical-stage biotechnology company based in London, UK and in California, US. Orchard is dedicated to transforming the lives of patients with rare disorders through innovative gene therapies. Orchard works in partnership with some of the world’s leading centers in gene therapy, including University College London, Great Ormond Street Hospital for Children NHS Foundation Trust, the University of Manchester and Manchester University NHS Foundation Trust, the University of California Los Angeles and Boston Children’s Hospital. In 2016 the company was named a Fierce 15 Company by Fierce Biotech. Also, Orchard and UCLA were awarded a $19 million grant from the California Institute of Regenerative Medicine (CIRM) in 2016 to advance the development of autologous ex-vivo lentiviral gene therapy in ADA-SCID. For more information, visit


Link to the Press Release

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